Commonly taken for heartburn or acid reflux, PPIs reduce stomach acid effectively. Long-term use (months to years) has been associated in studies with increased risks of acute kidney injury and chronic kidney disease progression, possibly through interstitial nephritis or other mechanisms.
Many people start them for convenience, but evidence suggests shorter courses or alternatives may lower potential concerns.
3. Certain Antibiotics (e.g., Aminoglycosides like Gentamicin, Vancomycin)
These fight serious bacterial infections but can accumulate in kidney tissues, causing direct tubular damage. Vancomycin and aminoglycosides often require monitoring in hospitals due to this risk.
For common infections, doctors typically choose less risky options when possible.
