Magnesium Supplements: Important Medication Interactions to Know Before You Start

3. Diuretics (Water Pills)

Some diuretics increase urine output to manage blood pressure, heart issues, or fluid buildup—and they can also flush out more magnesium through the kidneys over time. Long-term use might contribute to lower magnesium levels.

Common types:

  • Loop diuretics (like furosemide)
  • Thiazide diuretics (like hydrochlorothiazide)

If you’re on these, regular check-ins with your doctor about mineral levels can be helpful.

4. Proton Pump Inhibitors (PPIs for Acid Reflux)

Long-term use of PPIs reduces stomach acid, which over months or years can impair magnesium absorption from food and supplements, potentially leading to low levels.

Examples:

  • Omeprazole (Prilosec)
  • Esomeprazole (Nexium)
  • Lansoprazole (Prevacid)

Monitoring magnesium status is advised for those on extended PPI therapy.

5. Other Notable Mentions

  • Thyroid medications (like levothyroxine): Magnesium might affect absorption if taken simultaneously.
  • Certain blood pressure drugs (calcium channel blockers): Combined effects could influence blood pressure more than expected.
  • Gabapentin: Absorption may decrease when taken with magnesium.